Francois Pignon (DANIEL AUTEUIL) is a forty-something accountant at a condom company who's just accidentally overheard that he's about to be fired. This seems to be the last straw for Francois who still hasn't recovered from his wife, Christine (ALEXANDRA VANDERNOOT), leaving him two years ago, or the fact that their 17-year-old son, Franck (STANISLAS CREVILLÉN), essentially wants little or nothing to do with him.
Contemplating jumping from his balcony, Francois is interrupted by his new neighbor Jeanne-Pierre Belone (MICHEL AUMONT), who assures him that things aren't that bad and that he'll figure out a way for Francois to save his job. His plan turns out to be superimposing Francois' head onto the photo of a gay couple, anonymously mailing it to his company, and then letting the politically correct chips fall where they may.
Not surprisingly, word of the photos spreads like wildfire through the company, not only saving Francois' job, but also having the big boss, Mr. Kopel (JEAN ROCHEFORT), telling everyone to lay off the gay jokes and treat Francois, who's straight but doesn't deny the rumors lest the ruse be discovered, with kid gloves.
While Francois' immediate boss, Ms. Bertrand (MICHÈLE LAROQUE), and coworker, Ariane (ARMELLE DEUTSCH), are both suspicious and surprised about this revelation, the firm's PR director, Guillaume (THIERRY LHERMITTE), decides to teach the company's resident homophobe, Félix Santini (GÉRARD DEPARDIEU), a lesson by stating that his job is in jeopardy if he doesn't become Francois' good friend.
As the reluctant worker does just that, Francois must contend with everyone else, including his estranged family, changing their opinions and attitudes toward him as he finds his new identity liberating and himself finally growing as a person.