Eve (MEG RYAN), Georgia (DIANE KEATON) and Maddy (LISA KUDROW) are three adult women who, despite being sisters, are distinctly different and don't always get along that well. Georgia, the oldest, is busy running her self-titled magazine that's celebrating its fifth anniversary. Maddy, the youngest, is an actress on a soap opera.
Meanwhile, Eve, the middle child, finds herself being the one who has to care for their 79-year-old father,
Lou (WALTER MATTHAU), despite having a career of her own as an event planner, not to mention a husband, Joe (ADAM ARKIN), and son, Jesse (JESSE JAMES). A cantankerous veteran of the entertainment business, Lou has just been hospitalized for a week of tests and observation due to his progressively failing health and increasing forgetfulness.
While Georgia and Maddy care about their father, they'd rather Eve deal with the day-to-day stress of caring for him. Of course, that doesn't sit well with her, particularly since she worries that the next phone call will probably be bad news about him, and that he continually asks to see their estranged mother, Pat (CLORIS LEACHMAN), who wants nothing to do with her former family.
As the sisters stay in touch via phone and Eve gets some moral support from a local doctor, Omar Kunundar (DUKE MOOSEKIAN) and his wise mother, Ogmed Kunundar (ANN BORTOLOTTI), they recall times gone by while hoping and waiting to see if their father will be okay.