Dr. Sullivan Travis (RICHARD GERE), a.k.a. "Dr. T," is a Dallas-based gynecologist whose demeanor and practice are so popular that his schedule is always booked and his waiting room always packed with clients from across the city, including many upper-crust women. While his chief nurse, Carolyn (SHELLEY LONG) tries to control the crowd, Dr. T's meticulous but compassionate ways - and his overriding love and adoration for all women -- continually result in his appointments falling behind schedule.
At home, various women also surround and influence the doctor's life. His beautiful wife, Kate (FARRAH FAWCETT), is beginning to suffer from a disorder called the Hestia Complex that progressively renders her more childlike everyday. Their cheerleader daughter, Dee Deed (KATE HUDSON), is soon getting married, while her Kennedy-conspiracy buff sister, Connie (TARA REID), is jealous of the attention she's receiving and suspicious of Dee Dee's "friendship" with Marilyn (LIV TYLER), her out of state maid of honor. To complicate matters, Dr. T's boozing sister-in-law, Peggy (LAURA DERN), has recently moved in with her three young girls.
Overwhelmed by all that's occurring in his life, the doc spends time hunting and golfing with his friends including Harlan (ROBERT HAYES), Bill (MATT MALOY) and Eli (ANDY RICHTER). During the latter, he meets his country club's new assistant golf pro, Bree Davis (HELEN HUNT), a pretty and self-assured woman. As she wins him over because she's the one woman in his life who isn't needy toward him in one way or another, Dr. T. falls for her and must then figure out how to handle everything that's transpiring in his life.