It's been three years since fashion designer Cruella De Vil (GLENN CLOSE) was locked up for dognapping scores of Dalmatian puppies in hopes of making a signature fur coat from their spotted skins. Now reportedly reconditioned to love dogs and hate furs, Cruella's paroled under the condition that with any repeat offense she'll forfeit her entire fortune of eight million pounds.
Her personal assistant, Alonso (TIM McINNERNY), isn't convinced of her change, which also holds true for Chloe Simon (ALICE EVANS). She's a probation officer responsible for recent parolees such as Ewan (BEN CROMPTON), a released convict who helps his friend, Kevin Shepherd (IOAN GRUFFUDD), run the cash poor Second Chance animal shelter. Her reservations stem from the fact that her dog, Dipstick, was one of the formerly abducted pups and now has three Dalmatian puppies of his own, Little Dipper, Domino and Oddball, the latter of whom is void of any spots.
After buying Second Chance, Cruella's conditioning reverses, and she returns to her old ways. As such, and to avoid losing her fortune, she enlists the aid of French furrier Jean Pierre Le Pelt (GERARD DEPARDIEU) as her front man for abducting the puppies for her signature fur coat. As the two of them and Alonso set out to kidnap the pups, Chloe, Kevin, Dipstick and Waddlesworth (voice of ERIC IDLE), a free-speaking macaw, do what they can to stop them and free the pups.