It's 1967 Dublin, and Agnes Browne (ANGELICA HUSTON), has just found herself a widow with seven children, including oldest sons Mark (NIALL O'SHEA) and Frankie (CIARAN OWENS), to raise. Of course, her best friend Marion Monks (MARION O'DWYER) is there for emotional support, but Agnes finds that she must borrow money from the local loan shark, Mr. Billy (RAY WINSTONE), to pay for her husband's funeral.
That out of the way, Agnes joins Marion in selling fruit and vegetables at the local street market, hoping to make enough money to support her family and pay back Mr. Billy and his right-hand thug, Micko (GAVIN KELTRY). Although her life is hard, Agnes enjoys life, a good laugh, and the thought of seeing singer Tom Jones when his concert tour passes through town.
As time passes by, Marion must not only contend with the hardships of being a single mother, but also with repeated encounters with Mr. Billy, an unexpected health crisis and the attention paid to her by a local French baker, Pierre (ARNO CHEVRIER), who's just set up shop nearby.