Leo (CHANNING TATUM) and Paige (RACHEL McADAMS) are a young husband and wife living in Chicago. They are head over heels in love with each other. He owns a recording studio and she is an up-and-coming sculptor and artist. On the way home from the movies one wintry night, a snow plow barrels into their stopped car from behind, sending Paige through the windshield. She is in a coma for days and awakes to severe memory loss. She can't remember her life with Leo.
She does, however, remember her years before giving up law school; moving from the suburbs to the city; and becoming estranged from her father, Bill (SAM NEILL); mother, Rita (JESSICA LANGE); and sister, Gwen (JESSICA McNAMEE). They re-enter her life and try to take control of her recovery, urging her to move back home with them after five years of not speaking. Leo insists she come home with him and try to fill in what is still missing - a strategy her physician, Dr. Fishman (WENDY CREWSON), agrees with.
Nothing is familiar to Paige back in Chicago, and she soon finds herself drawn to what she knows. Even worse for Leo, she finds herself attracted to Jeremy (SCOTT SPEEDMAN), her former fiancé who she broke up with shortly before their wedding years earlier. Growing further apart, Leo decides to woo his wife all over again in an effort to win her heart and save their marriage.